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Biochemistry , 70 , 200214
28 In another study using an Alzheimers model of mice that develop amyloid plaque deposits by 6 months of age, a 30-day oral administration of HEM resulted in fewer plaque deposits in microglia and astrocytes in the cerebral cortex and hippocampus
The platform operates on the principle of generating uniform microdroplets that encapsulate m6Acontaining genes and the CRISPR/Cas13a detection system, wherein Cas13a recognizes the NCOA4 sequence and cleaves the reporter gene, resulting in amplified fluorescent signals within 20 min
