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Edaravone Edaravone, approved in Japan (2015) and the US (2017), represents another major pharmacological option, particularly indicated for early-stage ALS (23)

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Such trace metals are usually deposited in the cytoplasm, cell wall, and vacuole, and the detoxification is governed by selective exclusion of metals, metal retention, enhancement of the enzymatic system for triggering tolerance, immobilization by the cell wall, and extracellular carbohydrates, formation of complexes by binding with phytochelatins which are peptides of low-molecular-weight or by ligands, organic acids and amino acids, and lastly by compartmentalization [273]

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274,275 1,2-Dioleyloxy-3-dimethylaminopropane (DODMA) and its analog 1,2-dioleyloxy-3-(dimethylamino) propane (DODAP) were among the first ILs used for RNA delivery

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Unlike autoimmune diseases such as multiple sclerosis, there is no evidence of immune activation or inflammatory lesions in the CNS of people with autism [428]

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