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The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor

Heterogeneity in NMA was high (between-study variance=5.75, I 2 =96%) compared also to the Rhodes et al 22 empirical distribution (median 0.05, 95% range: 0.00 7.56)

For instance, in cardiomyocytes, mitochondrial impairment may primarily disrupt energy production essential for cardiac contraction, while in neurons, it can lead to synaptic dysfunction and neurodegeneration [32]

This rapid increase supports the maintenance of the corpus luteum, which in turn produces progesterone to sustain the uterine lining and support the developing embryo