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The peptide's ability to activate multiple melanocortin receptor subtypes contributes to its diverse physiological effects, though this non-selectivity also accounts for various side effects including nausea, yawning, stretching, and transient facial flushing

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The study suggested that AA-2G acts through in vivo hydrolysis to release ascorbic acid, with acyl modification enhancing bioavailability, and the branched structure potentially providing additional antitumor mechanisms

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