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Images were captured using a confocal laser-scanning microscope to assess NF-B p65 nuclear translocation

Constipation management Constipation responds well to proactive management: Increase water intake to at least 2.5 to 3 liters daily Add fiber gradually through diet or supplementation (psyllium husk works well) Maintain physical activity as movement stimulates gut motility Consider magnesium supplementation (magnesium citrate or oxide), which has natural laxative properties Avoid foods that worsen constipation such as processed foods, excessive dairy, and refined carbohydrates These strategies align with general recommendations for anyone experiencing peptide-related digestive changes

Limited health care access and resources further strengthens the burden of non-communicable diseases seen in ongoing transition phase countries (14, 40)

Injectable peptide hydrogels: Researchers have developed self-assembling peptide hydrogels that can be injected directly into the nucleus pulposus