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Description
In vitro COMT inhibition assays demonstrated that the tolcapone-loaded PLGA nanoparticles achieved comparable enzyme inhibition efficacy to free tolcapone, confirming therapeutic retention which was achieved in addition to a controlled-release profile and reduced cytotoxicity

doi: 10.1016/j.jtcm.2018.03.002 78 PanXLiuYLiuLPangBSunZGuanSet al

When you increase the dose, you are essentially resetting the adaptation clock
CAS No.: 9013-66-5 Storage: Please store the product under the recommended conditions in the Certificate of Analysis