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983 DFO and DFP have also been reported to have a similar effect

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The potential molecular mechanisms underlying these effects included disturbances in redox homeostasis (as evidence by the enhanced production of ROS and reactive nitrogen species), failure of enzymatic and nonenzymatic cytoprotective mechanisms involving the glutathione system as well as nuclear factor kappa B (NF-B) and fibroblast growth factor 2-mediated pathways, and impaired mitochondrial function

Hepatic Chylomicron Remnant Uptake Chylomicron remnants, containing primarily cholesteryl esters, apoE, and apoB-48, are then delivered to, and taken up by, the liver