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Among the possible serious complications are anterior uveitis and (pigmentary) glaucoma
After AWC asymmetry is established via transient signaling during embryogenesis, one of the most important pathways that maintain AWC ON and AWC OFF identities throughout the life of the animal is the cGMP pathway 27

PMID 17368845
People most commonly use the pairing to support focus and memory, steadier mood during stress, healthy cell membrane function, and liver support related to fat metabolism