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Enhancing TNBC chemo-immunotherapy via combination reprogramming tumor immune microenvironment with immunogenic cell death

3.1.1.3 Allopurinol and Nicotinamide In vitro studies show that allopurinol and nicotinamide prevent superoxide-induced growth of orbital fibroblasts in TAO patients (109)

Based on the importance of PTMs in mitochondrial dysfunction and hepatocyte cell death in DILI, ALD, and MASLD models, the contributing roles of various PTMs in cocaine-mediated mitochondrial dysfunction and hepatotoxicity are expected, although this needs to be verified by future research