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In individuals with trisomy 21, intellectual disability that accompanies the condition can make it difficult to identify cognitive change, and decline in functional independence may be more helpful in identifying change or assigning an initial stage

Abstract Significance: The antiulcer peptide, stable gastric pentadecapeptide BPC 157 (previously employed in ulcerative colitis and multiple sclerosis trials, no reported toxicity (LD1 not achieved)), is reviewed, focusing on the particular skin wound therapy, incisional/excisional wound, deep burns, diabetic ulcers, and alkali burns, which may be generalized to the other tissues healing