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Using HD mouse and cell models, we demonstrated that TFEB and TFE3 are sequestered in muHTT aggregates, and muHTT proteins associates with LMP triggering the translocation of LGALS3 to the lumen of lysosomes, with a close relation between polyQ size and severity of these events

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Using glutathione to protect collagen fibers from free radical damage that helps support healthy skin elasticity and slow down the aging process