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One adduct formed by non-enzymatic methyglyoxal glycation is the hydroimidazolone MG-H1, which is formed by modification of the arginine guanidino group (Fig

However, keeping an elevated intracellular ROS level within AML cells without altering their viability and proliferation potential requires the establishment of a set of detoxification mechanisms to support their continued growth [33]

Clinical trials are necessary to determine the appropriate dosage for humans

It should not be ignored that inhaled nano-based drug delivery system has certain limitations, which requires high parameters such as particle shape, size and charge, so it has certain challenges in design