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Description
Many chemotherapeutic drugs target DNA topoisomerases and interfere with DNA replication to exert their anti-tumor activity [128]
Elucidation of this substrate-turnover-dependent regulation of CDO activity began with the discovery of this rare intramolecular cross-link between active-site residues Cys93 and Tyr157 in the X-ray crystal structure of CDO (Simmons et al
Methods 11 , 629632 (2014)
Although GOAT can transfer fatty acids ranging in size from acetic to palmitic acid onto des-acyl ghrelin, GOAT prefers medium-chain fatty acids as its substrates 9
