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251 Impaired neurotrophic support In DPN, levels of neurotrophic factors are significantly reduced due to hyperglycemia-induced metabolic disturbances

M., and Georgescu, E

We also evaluated the expression of cell cycle regulators (Cdkn1a (p21 WAF1/CIP1 ), Cdkn2a (p16 INK4A ), and Trp53 (p53)), senescence-associated -galactosidase (SA--Gal), and the dipeptidyl peptidase DPP4 (CD26) cell surface protein as cellular senescence biomarkers

Am J Physiol Regul Integr Comp Physiol 320(4):R471-R87 2021 PMC8238148 Anekonda VT, Thompson BW, Ho JM, Roberts ZS, Edwards MM, Nguyen HK, Dodson AD, Wolden-Hanson T, Chukri DW, Herbertson AJ, Graham JL, Havel PJ, Wietecha TA, O'Brien KD, Blevins JE