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Considering that the rate constant of superoxide radical dismutation by SOD1 is 2 10 9 M 1 s 1 and assuming concentrations of SOD1 and vitamin C = 10 M and 5 mM, respectively, vitamin C removes approximately 8% of the cytoplasmic superoxide radical

Injectable protocols mirror this timeline because the biological process is the same: fibroblast stimulation, collagen deposition, and tissue remodeling all operate on a multi-week timescale

Mild redness, itching, or warmth may occur at the injection site due to coppers vascular effects

Treatment (i.p.) of BALB/c mice with furan for 7 days resulted in increased serum levels of reactive oxygen species (ROS) and 8oxodeoxyguanosine as measured by ELISA (Wang et al., 2014a)