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doi: 10.1210/clinem/dgaa430 29 GerebenBMcAninchEARibeiroMOBiancoAC

Hyperthyroidism symptoms include: Unexplained or unintentional weight loss Fast or irregular heartbeat Anxiety and nervousness Irritability Increased appetite Sweating Fatigue Insomnia Its more common for older adults to have either no symptoms or subtle ones, such as an increased heart rate, heat intolerance, and fatigue when performing routine tasks

Thus, increasing anaplerosis through GDH by producing more glutamine-derived glutamate could rescue the ability of the neuron to metabolize glutamate taken up from the synapse potentially avoiding excitotoxicity by excess glutamate levels in the synapse

Goman AM, Lin FR