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As revealed by RP-HPLC/MALDI-TOF analysis, treatment of 1.2 M M pro with 2 mM GSSG led to an estimated 45% monoglutathionylation (only an estimate based on the mass abundances), whereas treatment with 10 mM GSSG led to mono- (11%), di- (50%), and tri-glutathionylation (35%), with less than 4% of M pro remaining unmodified (Figure 1C)
247 In animal models, Wnt/-catenin signaling is reportedly attenuated during cerebral I/R, leading to increased BBB permeability and damage due to the downregulation of TJ protein in microvascular ECs
Mouatt-Prigent et al., 2004)
Zhao Y, Li A, Jiang L, Gu Y, Liu J
