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66 FPN has also been shown to modulate cell sensitivity to ferroptosis in vitro, 68 and FPN inhibitors can be used to modulate ferroptosis

Over time, however, prolonged persistence under therapeutic pressure may increase the likelihood of genetic diversification and eventual acquisition of stable resistance mechanisms 13 , although the timing and molecular determinants of this transition remain to be further explored

While prior reviews have covered curcumins chemical composition and biological activities, this work goes further by integrating the latest advancements in several key areas

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