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Common Xenobiotic Induction Pathways and Effect On Liver Morphology Induction Involving Constitutive Androstane Receptor Barbiturates and chemicals that induce CYP2B initially interact with the constitutive androstane receptor (CAR) that translocates to the nucleus and dimerizes with the retinoid-X-receptor (RXR)
Oxygen and oxidative stress Atmospheric oxygen reacts with susceptible amino acid residues, particularly during extended room temperature storage
