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NGF-like neuroprotection pathways TrkA receptor engagement: Nerve growth factor (NGF) critical for neuronal development and maintenance

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Immediately following stroke, microglia take on an anti-inflammatory and tissue repair-associated phenotype, expressing CD206, Arg1 , Ccl22 , Il10 , and Tgfb1 , with enhanced phagocytic activity for clearing damaged tissue and supporting neuronal recovery and reinnervation [151]

Importantly, in vivo evaluation indicates that the Ag/apatite decorated multifunctional scaffolds exhibited attractive in vivo antibacterial efficacy and resulted in excellent bone ingrowth and osseointegration in an infected critical-sized bone defect