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The development of antiviral drugs and basic principles of drug discovery Development of antiviral drugs Approval of idoxuridine (the first approved antiviral drug) In 1963, idoxuridine (Fig

Following NET or apoptosis induction, neutrophils were pelleted and resuspended in 1 annexin V binding buffer (eBioscience), containing annexin V (5 ng ml 1 ) and either propidium iodide (100 ng ml 1 , P4170, Sigma) or DAPI (40 nM, 422801, BioLegend)