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Following FOXO4 displacement, the released p53 undergoes nuclear export and mitochondrial translocation, activating the intrinsic apoptosis pathway via BAX upregulation and BCL-2 downregulation, culminating in caspase-3 cleavage and apoptotic cell death

Molecules 19:1906619077 Dickinson R, de Sousa SL, Lieb WR, Franks NP (2002) Selective synaptic actions of thiopental and its enantiomers

AMPK induces the expression of proteins involved in OXPHOS, such as peroxisome proliferator-activated receptor (PPAR)- coactivator (PGC) 1, a transcriptional coactivator that promotes mitochondrial biogenesis 63 , and the activities of mitochondrial enzymes, including succinate dehydrogenase (SDH) 64

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