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This more easily crosses the mitochondrial membrane than the nucleotides of adenine, besides being present at higher levels in the intracellular medium
K., Roach, R
This hypercatabolism is evident by our data demonstrating depletion of amino acids and upregulation of the urea cycle as judged by elevated levels of urea cycle metabolites such as citrulline
These substitutions protect against dipeptidyl peptidase-IV (DPP-IV) cleavage, the enzyme that destroys natural GHRH within minutes (Alba et al., J Med Chem 2006)
