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Frowned upon yes
Although -synuclein is frequently implicated in PD pathogenesis, other proteins such as PTEN induced putative kinase 1 (PINK1), Parkin, DJ-1, leucine-rich repeat kinase 2 (LRRK2) have been strongly linked to familial forms of PD 6,7
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Strategies such as covalent stabilization, adjuvant incorporation, and cell-penetrating peptide design have been proposed to enhance their efficacy (Li et al., 2019
