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In addition to its proteolytic cascades, uPAR are also involved in signaling events leading to cell proliferation, migration, angiogenesis, remodeling of the cell adhesion, cytokine release, priming of neutrophil for oxidant production and chemotaxis, all of which play a key role in the development, implantation and metastasis of tumors [88, 248]

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Burk RF, Norsworthy BK, Hill KE, Motley AK, Byrne DW
