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The histopathological hallmarks of ALD include steatosis, hepatocyte ballooning, and neutrophil infiltration (Stickel et al., 2017), mirrored biochemically by elevated serum transaminases, dyslipidemia, diminished antioxidant enzyme activities, and increased pro-inflammatory cytokines (Li et al., 2025)

The idea of fundamentally altering a core feature of your appearance through a biological 'hack' is compelling

However, it has also been shown to reduce body fat in healthy individuals

Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans
