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While MYC is a well-characterized human oncogene, systemic suppression of MYC as a targeted human longevity intervention is currently unproven and remains confined to transgenic mouse models and in vitro assays

[DOI] [PubMed] [Google Scholar] Iwanaga M, Mori K, Iida T, Urata Y, Matsuo T, Wasunaga A, Shibata S, Kondo T

however, these findings highlight one of the complexities of using antioxidant therapies, as increased GPx1 activity was correlated with enhanced ERK1/2 activation when analyzing memory, whereas increased GPx1 correlated with a decrease in ERK1/2 activation in the hypoxic preconditioning study, presumably due to the loss of hydrogen peroxide-mediated ERK1/2 activation