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2011;6:e24585

5 Additionally, central nervous system (CNS) complications are more prevalent in individuals with diabetes, with up to 50% experiencing some degree of cognitive decline

36 As a result of this, the T-cell receptor of potentially autoreactive T cells will not interact with the HLA-groove/auto/self-peptide complex, and thus 90% of the autoreactive T cells, that normally die in the first days of life, will survive and become drifting mines in the peripheral lymphoid organs, ready, if activated, to kill cells that are the potential target of an autoimmune attack, such as beta cells in the pancreatic islets

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