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(B) Relative abundance of proteins involved in Ca 2+ handling expressed relative to WT levels (from proteomic data)

Phosphorylation of GSK3 at Ser9 inhibits its kinase activity, thereby stabilizing -catenin and repressing the adipogenic regulator PPAR, ultimately modulating adipogenesis and the progression of obesity [62, 63]

CpG-rich regions (so-called CpG islands) are found typically in the proximal promoter regions of genes, and in normal cells are usually unmethylated

Nano-HBOCs for hemorrhagic shock therapy Hemorrhagic shock (HS) is a complex condition caused by a reduction in the effective circulating blood volume [87, 88], resulting in irreversible tissue hypoxia [89], eventually triggers circulatory failure [90]