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During metastatic evolution, cancer cells exhibit context-dependent metabolic switching, such as the processes of glycolytic metabolism or oxidative phosphorylation of lymph node metastasis or the reliance on fatty acid oxidation to balance the redox of latent brain metastatic cells (183)

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810 CsA@ApoFn reduces the content of unstable iron pool and lipid peroxide by increasing the expression of GPX4 protein, thereby inhibiting ferroptosis in ischemic cardiomyocytes, 810 providing a promising strategy for the treatment of myocardial I/R injury