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In the PROVE IT-TIMI 22 study, patients with RIR, defined by an LDL-C 2 mg/l (44% of the total), presented an age-adjusted annual event rate of 3.1% compared to 2.4% in patients with hs-CRP 2 mg/l (33% of all patients) presented a crude event rate of 33.7% at 7-year follow-up (defined as cardiovascular death, heart attack or non-fatal stroke) compared to 28% in patients with a hs-CRP 3 mg/l (34.9% of the total) had a cardiovascular event rate of 3.59 per 100 person years, compared to 1.96 in those with hs-CRP 3 mg/l presented a greater reduction in events during treatment absolute risk reduction 2.6% (HR 0.80

Pachmann K, Zhao S, Kantarjian H, Andreeff M

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Since semaglutide reduces appetite and helps control calorie intake, increasing physical activity becomes an important part of maintaining muscle mass and increasing overall metabolic burn