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Induced rodent models, while useful, exhibit varying degrees of reproducibility and inconsistencies in the extent of RGC damage they produce ( Figure 3 The slow progression of glaucoma, the variability in its pathogenesis, and the need for clear evidence beyond normal IOP reduction make clinical investigations into neuroprotection particularly challenging

in: PubMed | Google Scholar | 1 Department of Surgery, Massachusetts General Hospital (MGH), Harvard Medical School, Boston, Massachusetts, USA

Lutz PE, Tanti A, Gasecka A, Barnett-Burns S, Kim JJ, Zhou Y, et al

Hippocampal Glutamate Level and Glutamate Aspartate Transporter (GLAST) Are Up-Regulated in Senior Rat Associated with Isoflurane-Induced Spatial Learning/Memory Impairment