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[26] [27] [4] The FDA originally recommended it for individuals 60 years of age or older who are not severely allergic to any of its components and who meet the following requirements: [28] [29] do not have a weakened immune system due to HIV/AIDS or another disease or medications (such as steroids, radiation and chemotherapy) that affect the immune system

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Without sufficient methylfolate and vitamin B12, MTR wont convert as much homocysteine to methionine, leading to a buildup of homocysteine and limiting methionine

2 Vitamin B12induced acne can be differentiated from acne vulgaris by the presence of pruritus, correlation between drug use and eruption, sudden onset, patient age, and the absence of comedones and microcysts