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Neuropsychiatric disorders: predominance of astrocytic atrophy and loss of function Mood disorders Major depressive disorder (MDD) Decreases in the total number of glial cells and astrocytes are the main and most consistent histopathological hallmark of MDD post-mortem brains

The HC did not fulfill the exclusion criteria above, were devoid of chronic pain, and did not take regular sleep medication, antidepressants, NSAIDs, analgesics, or anticonvulsants

The most devastating consequence of this impaired lipid clearance is accelerated atherosclerosis, which manifests as premature coronary artery disease and myocardial infarction, often occurring before age 50

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