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No adverse events associated with LC administration were recorded at a dose 6 g/day for 12 months of supplementation in the patients with acute anterior myocardial infarction [87], or at a dose 1.274 g/day (range 0.33 g/day) and duration 348 days (range 93744 days) in patients with liver cirrhosis [88]

Al-Majed and colleagues [140] found that carnitine deficiency and oxidative stress are risk factors during development of cisplatin (CDDP)-induced cardiomyopathy and that carnitine supplementation, using propionyl-l-carnitine, prevents the progression of CDDP-induced cardiotoxicity

TMA can be catalyzed as TMAO by flavin mono-oxygenase 3 (FMO3), a key rate-limiting enzyme in the liver

Carnitine protects against MPP+-Induced neurotoxicity and inflammation by promoting primary ciliogenesis in SH-SY5Y cells