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Subsequent research work in human subjects may be required to collect additional data on safety, tolerability, pharmacokinetic properties and efficacy in the target group of patients before a compound or drug can be implemented clinically [265, 266]

Switching the C S domain between the two NRPSs lead to the corresponding switch in starter unit size and afford the C2-holrhizin A ( 388b ) and C8-rhizomide A ( 389b ) (Figure 95)

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