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Notably, NRF2-inducing compounds, such as tBHQ and sulforaphane, modify distinct KEAP1 residues from oxidation by ROS, thus allowing for an additive effect in the presence of oxidative stress (Suzuki et al., 2019

Wang H, Yang C, Doherty JR, Roush WR, Cleveland JL, Bannister TD

Furthermore, gene therapy approaches like an adenoviral-based gene therapy drug named Gendicine (recombinant human p53 adenovirus) became the first approved gene therapy for p53 restoration by the China Food and Drug Administration (CFDA) [29]

It didnt really inspire confidence, he admitted
