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Notably, the induction of Plin5 suggests improved coupling between lipid droplet lipolysis and mitochondrial oxidation, allowing fatty acids to be efficiently directed to energy metabolism rather than accumulating as toxic intermediates

Interactions between genetic and environmental factors affecting mother before and during pregnancy, e.g., chemicals (arsenate, mercury, lead, polychlorinated biphenyls, toluene, and pesticides), perinatal injuries, infections during pregnancy, hypoxia, preterm delivery, and intensive antibiotic therapies during pregnancy disturbing embryogenesis, are thought to significantly impact ASD occurrence [2]