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Description
Transforming growth factor-3 (TGF-3) exerts a protective effect on hippocampal neurons by binding to the TGF- type receptor I (TGF-RI), this neuroprotective effect is mediated by activation of the nuclear transcription factor 2 (Nrf-2)/Kelch-like ECH associated protein 1 (KEAP1)/hemo oxygenase 1 (HO-1) pathway, which strengthens the antioxidant defense and supports neuronal survival [44]
71 As a result, endotoxins such as lipopolysaccharide (LPS) translocate across the epithelial barrier and reach the liver via the portal circulation
Lipscomb G
FDAFood and Drug Administration
