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Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditions
However, RJ pretreatment abolished the Cd-induced impairment in the cellular detoxification system by enhancing Nrf2, HO-1, and NQO1 protein expressions and restraining NF-B protein expression (Fig
Bidirectional signaling, outside-in (matrix influencing cell behavior) and inside-out (cell modulating adhesion strength)
For skin specifically, this matters because the accumulation of senescent fibroblasts in aging dermis is one of the primary drivers of collagen loss
