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Studies have demonstrated that EGCG can directly influence mitochondrial bioenergetics by enhancing the efficiency of the electron transport chain and promoting mitochondrial biogenesis through activation of key signaling pathways, particularly peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1)

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The activation of macrophages is also followed by translocation of mitogen-activated protein kinases (MAPKs) to the nucleus where they phosphorylate the transcription factor NF-kappa B, thus activating a pro-inflammatory immune response