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For instance, delivering genes that encode neurotrophic factors like GDNF (glial cell line-derived neurotrophic factor) could support dopaminergic neurons and slow down the progression of the disease

In this context, although while studies conducted in meta-analyses suggest that a consistent circadian rhythm is not observed, possibly due to small sample sizes, a recent study reported that sphingolipids and phospholipids exhibit higher concentrations in the evenings, with diacylglycerols and triacylglycerols showing more pronounced circadian variation compared to phospholipids and sphingolipids [3, 33]

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10.3390/ijms140815260 Int