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Our work herein identifies a key role for MC-derived histamine release and subsequent H4R activation in driving clinical and histopathologic severity in UC-like inflammation by regulating innate neutrophil recruitment and associated mucosal injury, likely via coordinating the downstream local production of IL-6 and neutrophil-attracting chemokines

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Presumably, this was due to increased degradation of these proteins, which occurs in the absence of ALS

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Cancer Med (2019) 8:701831

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