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Second, as senescent cells accumulate, they produce, for unclear reasons, low levels of inflammatory mediators, a phenomenon which has been termed inflammaging, particularly when evident in older people [3033]

To build on our previous findings with ex vivo longitudinal spinal cord slice cultures (Hawker et al., 2024), we next looked at lysolecithin (LPC) to model sustained demyelination in ex vivo brain slice cultures
