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8-OHdG has been strongly implicated in carcinogenesis progression

Although the pKa value of Cys-thiol GSH is relatively high (8.99.4) [3], indicating low reactivity in the intracellular environment, its central role in protecting cells from reactive oxygen/nitrogen species (RONS) is based on enzyme-catalyzed reactions, efficient recycling pathways, as well as the mass effect achieved by its high intracellular concentrations (210 mM)

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Pairing with vitamin C can help keep glutathione in its reduced, active state