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The interface with the second largest buried surface area in the Tyk2 crystal lattice did place the C- and N-termini in close enough proximity to be linked by the interdomain linker, and this interface was investigated in detail and mutational data did support the biological significance of this interaction surface

It stimulates angiogenesis to improve blood supply to damaged tissues, enhances fibroblast activity for superior collagen formation, and modulates inflammatory cascades to optimize the healing environment

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