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Due to the complex mechanism of PF and the characteristics of multi-component and multi-target of traditional Chinese medicine, biotechnology such as network pharmacology and metabolomics can be used to clarify the active ingredients and corresponding disease targets of MMDD in the treatment of PF in the future, so as to provide a reference for the development and clinical treatment of traditional Chinese medicine

Apart from the above described diagnostic criteria, there has been suggestion by Hubers et al

This effect is due to the increased availability of glutathione for its direct cidal effect as well as the protection against RNS release and the formation of GSNO generated during oxidation stress

Oxidative stress can also cause GCs inflammation and apoptosis