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The metabolic and weight loss benefits of GLP-1 medications are substantial and typically outweigh the nuisance of constipation

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[PubMed] [Google Scholar] 276.Greulich W, Fenger E

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More recent examples include GLP1 (glucagonlike peptide1) agonists such as semaglutide and tirzepatide, sold under brand names including Wegovy and Zepbound

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Jumping from 0.25 mg to 1.0 mg triggers severe nausea and vomiting in most users

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