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Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: Implications for the pathogenesis of obesity

Spegel P, Sharoyko VV, Goehring I et al (2013) Time-resolved metabolomics analysis of beta-cells implicates the pentose phosphate pathway in the control of insulin release

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This observation is interesting, as NFB activation is considered antiapoptotic and pro-survival, in part, due to its role in augmenting the expression of IAPs, which attenuate caspase activation