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Importantly, drug-resistant tumor are more sensitive to lipid peroxidation, which undoubtedly makes, the combination of System X c /GSH/GPX4 axis-based ferroptosis inducers with chemotherapeutic agents may become a new strategy for the treatment of drug-resistant solid tumors (Viswanathan et al., 2017)

However, human studies directly linking specific cytokine levels to idiopathic tinnitus have yielded mixed results, with some showing alterations in cytokines like IL-10 and IFN- (Mennink et al., 2024)and others finding correlations between tinnitus intensity and IL-6 or TNF- levels (Tanaka et al., 2024), while yet another study in older adults found no broad cytokine differences except for IL-10 in males (Tanaka et al., 2024)